PFAS Chemicals Harm the Immune System, Decrease Response to Vaccines, New EWG Review Finds

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By Tasha Stolber, Environmental Working Group

Toxic PFAS chemicals, notorious for contaminating drinking water supplies across the U.S., are harmful to nearly every human organ, and the immune system is particularly vulnerable. PFAS mixtures, which are used in a variety of consumer products, can be found in the body of nearly every American and in the developing fetus.

Now studies suggest a connection between PFAS exposure and health problems, including suppressed immune function, lower vaccine effectiveness, hypersensitivity and greater risk of autoimmune diseases. A recent review of human epidemiological studies by Rappazzo et al. shows that PFAS may influence antibody response to vaccination and other health issues, such as asthma.[i]

Tests commissioned by Environmental Working Group, Commonweal and Rachel’s Network, in 2005 and 2009, revealed that American babies are born contaminated, via the umbilical cord, with PFAS and other toxic chemicals.[ii]

In a 2016 review of PFAS immunotoxicity,  the National Toxicology Program concluded that two of the most studied members of this large family of chemicals, PFOA and PFOS, can pose “an immune hazard to humans based on a high level of evidence that PFOA (and PFOS) suppressed the antibody response from animal studies and a moderate level of evidence from studies in humans.”[iii] These studies on antibody response are some of the strongest evidence of adverse effects on the human immune system.

The link between higher blood levels of PFAS and reduced antibody production following vaccination has been observed in studies of both children and adults. Although nutrition, exercise and other factors affect immune response, PFAS also clearly plays a role. The developing immune system may be particularly vulnerable to immunotoxicity in the earliest stages of life, so it is essential to protect children’s health from PFAS during that time.

A study published in 2017 reported that elevated PFAS levels during the first six months of infancy were associated with a weaker response to tetanus vaccination.[iv] In a 2013 study of 431 Danish children, PFOS and PFOA levels in blood were linked to decreased levels of antibodies against tetanus and diphtheria.[v] A drinking water guideline for PFOA and PFOS of 1 part per trillion, or ppt, would protect children from this health harm.

Research presented at a national conference on PFAS in June 2019 showed a lower response to the measles vaccination among a group of 237 West African children who had been exposed to low levels of PFAS.[vi] A 22 and 26 percent decreased antibody response was associated with a doubling of PFOS and PFDA levels in blood, respectively. Children at four and a half months in this study had levels of PFAS in their blood ranging from medians of 0.1 ng/ml, for PFHxS, to 0.68 ng/ml, for PFOA, and 0.77 ng/ml, for PFOS, demonstrating immunotoxicity even at very low levels. In 2008, EWG tested American newborns’ cord blood and found medians of 0.69 ng/ml for PFOA and 1.54 ng/ml for PFOS.[vii]

PFAS immunotoxicity can also affect vaccine response later in life, as PFOA levels in adults’ blood corresponded to reduced immunity from a flu vaccine.[viii] In a small study of adults, PFAS chemicals, especially in long-chain versions, were linked to decreased response following tetanus-diphtheria boosters.[ix]

Children are especially vulnerable to asthma, an example of immune system hypersensitivity also linked to exposure to multiple PFAS chemicals. A 2013 study of Taiwanese children was one of the first to connect nine PFAS chemicals with juvenile asthma, asthma severity and immune system markers.[x] A 2019 study connected the sum of PFAS in blood, as well as PFOS and PFHxS, with asthma in a study of Norwegian adolescents.[xi] A 2016 analysis related PFOS, PFOA and PFHxS levels with significant increases in adolescent food allergies, another immune system hypersensitivity.[xii]

Some studies also point to lower resistance to disease, yet another result of immune system suppression. Higher maternal levels of PFOS and PFOA during pregnancy were linked to increased fever in young children, which shows an increased risk of infections.[xiii] In another Norwegian study, prenatal PFAS exposure affected people’s ability to fight off cold and stomach infections.[xiv]

EWG’s child-protective drinking water standard for PFAS chemicals of 1 ppt represents a concentration that, according to current epidemiological research, would safeguard the immune system. This standard would ensure drinking water is not at risk but would not eliminate exposure through contaminated food, food wrappers, dust and consumer products, all of which would need to have lower levels of PFAS for the immune system to be protected.

The scientific research, including epidemiological studies, that shows damage to the immune system and decreased response to vital vaccines with early life PFAS exposure should strengthen the argument made to policymakers about a sweeping package of reforms to address the unfolding contamination crisis.

There are more than two dozen pieces of legislation before Congress that would speed the cleanup of contaminated sites; ban certain uses of PFAS chemical; and set a health-protective nationwide drinking water standard, among other measures.

EWG has urged the Trump administration and Congress to take a series of steps to protect the public from further exposure to PFAS chemicals, including:

  • Identify PFAS pollution sources and regulate discharges into the air and water.
  • Identify the scope of PFAS contamination through regular testing and monitoring.
  • Take PFAS out of consumer products.
  • Stop approving new PFAS chemicals.
  • Set and enforce PFAS cleanup standards.

Look for information about PFAS chemicals here.


[i] Rappazzo KM, Coffman E, Hines EP. 2017. Exposure to perfluorinated alkyl substances and health outcomes in children: A systematic review of the epidemiologic literature. International Journal of Environmental Research and Public Health. 14(7):691. Available at: https://www.mdpi.com/1660-4601/14/7/691/htm

[ii] Environmental Working Group and Commonweal. 2009 Human Toxome Project. Available at https://www.ewg.org/sites/humantoxome/

[iii] National Toxicology Program. 2016. NTP Monograph on Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid or Perfluorooctane Sulfonate. Available at: https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf

[iv] Grandjean P, Heilmann C, Weihe P, Nielsen F, Mogensen UB, Timmermann A, Budtz-Jørgensen E. 2017. Estimated exposures to perfluorinated compounds in infancy predict attenuated vaccine antibody concentrations at age 5-years. Journal of immunotoxicology, 14(1):188–195. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190594/

[v] Grandjean P and Budtz-Jørgensen E. 2013. Immunotoxicity of perfluorinated alkylates: calculation of benchmark doses based on serum concentrations in children Environmental Health. 12:35. Available at: https://ehjournal.biomedcentral.com/track/pdf/10.1186/1476-069X-12-35

[vi] Timmermann CAG, Jensen KJ, Nielsen F, Budtz-Jørgensen E, Benn CS, Grandjean P, Kisker AB. 2019. PFASs and decreased Vaccine Response in Guinea-Bissau Children. Conference Abstract. Per- and Polyfluoroalkyl Substances: Second National Conference. Northeastern University, Boston, Mass.

[vii] Environmental Working Group and Commonweal. 2009 Human Toxome Project. Available at https://www.ewg.org/sites/humantoxome/

[viii] Looker C, Luster M, Calafat AM, Johnson VJ, Burleson GR, Burleson FG, Fletcher T. 2014. Influenza Vaccine Response in Adults Exposed to Perfluorooctanoate and Perfluorooctanesulfonate. Toxicology Sciences. 138(1):76:88.

[ix] Kielsen K, Shamim Z, Ryder LP, Nielsen F, Grandjean P, Budtz-Jørgensen E, Heilmann C. 2016. Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates. J Immunotoxicology. 13(2):270-273. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739630/

[x] Dong GH, Tung KY, Tsai CH, Liu MM, Wang D, Liu W, Jin YH, Hsieh WS, Lee YL, Chen PC. 2013. Serum polyfluoroalkyl concentrations, asthma outcomes, and immunological markers in a case-control study of Taiwanese children. Environmental Health Perspectives 121(4):507-13. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620752/

[xi] Averina M, Brox J, Huber S, Furberg AS, Sørensen M. 2019. Serum perfluoroalkyl substance (PFAS) and risk of asthma and various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway. Environmental Research 169:114-121. Available at: https://www.sciencedirect.com/science/article/pii/S0013935118305760?via%3Dihub

[xii] Buser MC and F Scinicariello. 2016. Perfluoroalkyl substances and food allergies in adolescents. Environment International. 88:74-79. Available at: https://www.sciencedirect.com/science/article/pii/S0160412015301227?via%3Dihub

[xiii] Dalsager L, Christensen N, Husby S, Kyhl H, Nielsen F, Host A, Grandjean P, Jensen TK. 2016. Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1-4 years among 359 children in the Odense Child Cohort. Environment International. 96:58-64. Available at: https://www.sciencedirect.com/science/article/pii/S0160412016303245?via%3Dihub

[xiv] Granum B, Haug LS, Namork E, Stolevik SB, Thomsen C, Aaberge IS, van Loveren H, Lovik M, Nygaard UC. 2013. Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood. Journal of Immunotoxicology. 10(4):373-9. Available at: https://www.tandfonline.com/doi/full/10.3109/1547691X.2012.755580

Originally posted here.

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